The Misery of a Rigid Brain: How Neuroplasticity Deficits Contribute to Depression (Patreon Only Livestream #2)
What causes depression? A chemical imbalance? Nope. A moral failing? Definitely not. What about deficits in the brain's ability to change itself? Maybe. In this Patreon-only livestream, we will explore the connections between depression and neuroplasticity. Based on the Integrative Model proposed by Rebecca Price and the late neuroscientist Ronald Duman (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047599), we'll take a closer look at how deficits in neuroplasticity may be at the root of depression. In this livestream, I'll discuss: - How chronic stress and its impact on brain health can contribute to depression - The Integrative Model and its implications for understanding depression - Cognitive Control, The PFC, and Dopamine in Depression - The impact of depression on key brain regions such as the hippocampus and frontal cortex - How therapeutic techniques, including psychotherapy and pharmacology may be helping to increase brain plasticity in order to treat depression. Don't miss out! Patrons at the $4.99 tier and higher will have the opportunity to ask questions and engage in a live Q&A session. See you there! If you're watching this later and want access to the livestream when it airs, sign up for Sense of Mind's Patreon and get bonus content every month: www.patreon.com/senseofmind . You'll get: - Access to these exclusive monthly livestreams - Written (blog post) versions of all new videos, including this one! -- Don't forget to subscribe to this channel: @senseofmindshow And check out the podcast: https://podcasts.apple.com/us/podcast/sense-of-mind/id1603691298 Follow Sense of Mind on instagram: https://www.instagram.com/sense.ofmind/ -- Links to Content I Mentioned: - Dr. Ronald Duman's 2014 talk on ketamine and depression: https://youtu.be/yb6ZFCN7eSA - Dr. Rebecca Price's 2022 talk on ketamine and depression: https://youtu.be/DuotymRcWf0 - Huberman Lab ep. 34 on Depression: https://youtu.be/Xu1FMCxoEFc - The Social Brain ep. 14 on Neuroplasticity: https://youtube.com/live/9jrQfXaHrKM?feature=share -- References: - Price, R. B., & Duman, R. (2020). Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model. Molecular psychiatry, 25(3), 530-543. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047599/ - Zhou, F. C., Wang, Y. Y., Zheng, W., Zhang, Q., Ungvari, G. S., Ng, C. H., ... & Xiang, Y. T. (2017). Prospective memory deficits in patients with depression: A meta-analysis. Journal of Affective Disorders, 220, 79-85. - LeMoult, J., & Gotlib, I. H. (2019). Depression: A cognitive perspective. Clinical Psychology Review, 69, 51-66. - Dillon, D. G. (2015). The neuroscience of positive memory deficits in depression. Frontiers in psychology, 6, 1295. - Liberg, B., & Rahm, C. (2015). The functional anatomy of psychomotor disturbances in major depressive disorder. Frontiers in psychiatry, 6, 34. - Admon, R., Kaiser, R. H., Dillon, D. G., Beltzer, M., Goer, F., Olson, D. P., ... & Pizzagalli, D. A. (2017). Dopaminergic enhancement of striatal response to reward in major depression. American Journal of Psychiatry, 174(4), 378-386. - Belujon, P., & Grace, A. A. (2017). Dopamine system dysregulation in major depressive disorders. International Journal of Neuropsychopharmacology, 20(12), 1036-1046. - Whitton, A. E., Reinen, J. M., Slifstein, M., Ang, Y. S., McGrath, P. J., Iosifescu, D. V., ... & Schneier, F. R. (2020). Baseline reward processing and ventrostriatal dopamine function are associated with pramipexole response in depression. Brain, 143(2), 701-710. - Rutledge, R. B., Moutoussis, M., Smittenaar, P., Zeidman, P., Taylor, T., Hrynkiewicz, L., ... & Dolan, R. J. (2017). Association of neural and emotional impacts of reward prediction errors with major depression. JAMA psychiatry, 74(8), 790-797.