E108: Alcohol and Dynorphin

We drink expecting all of these good things to keep coming our way, but there’s a limit to the amount of alcohol that causes pleasure and good feelings. If you continue to drink after that point, you only get the bad stuff. In this episode you’ll learn why this drink limit exists and what’s going on in the brain to cause the discomfort, anxiety, depression and an emptiness that we experience after the alcohol wears off, and how opioid antagonists like Naloxone and Naltrexone work in the brain. Gill explains dynorphin, which is also known as the “feel bad” chemical, and how alcohol changes the dynorphin system in the brain to make us feel so miserable that we drink again to get relief. What to listen to next: E11: Why Alcohol Feels Good (Endorphins and Opioid Receptors) E62: Dopamine Deep Dive E67: How Alcohol Impacts Cortisol and Causes Cravings E106: What Happens in the Brain When We Are Overwhelmed (The Amygdala Hijack) E22: Why You Think Alcohol Helps Your Anxiety E64: Anxiety and Alcohol (Part 2) Resources I offer: Community: Living a Sober Powered Life https://www.soberpowered.com/membership Weekly emails on Thursdays where I explain the latest episode in more detail, share images to help you understand the concepts, share announcements, interviews, writing, discount codes and more. https://view.flodesk.com/pages/6107260617e156c4839768b5 Free resources https://www.soberpowered.com/free   Thank you for supporting this show by supporting my sponsors. Learn more: https://www.soberpowered.com/sponsors If you enjoyed this episode please consider buying me a coffee to support my work https://www.buymeacoffee.com/soberpowered Sources are posted on my website Disclaimer: all of the information described in this podcast is my interpretation of the research combined with my opinion. This is not medical advice. Learn more about your ad choices. Visit megaphone.fm/adchoices

Om Podcasten

Why do some people stay sober and others relapse back and forth? Getting sober isn’t about restriction, it’s about rewiring your brain to function without intensity, chaos, dopamine spikes, and avoidance. Hosted by Gill Tietz, a former biochemist turned sober coach, this show dives into the neuroscience of long-term sobriety — why some people relapse, why others stay free, and how to build the kind of brain that can handle life without alcohol. Each episode blends science, psychology, and real experience to help you strengthen the four pillars of neuro-resilience: 1. Neural Recovery – healing your brain’s reward and stress systems after alcohol. 2. Emotional Regulation – calming reactivity and learning to feel without numbing. 3. Cognitive Rewiring – changing the thought patterns that quietly pull you backward. 4. Behavioral Integration – designing routines and habits that make being sober your default. Whether you’re newly sober or years in, you’ll learn the research-backed tools and mind shifts that keep you steady, so sobriety stops feeling like something you’re trying to want and starts feeling like who you are. This is hard work. If you want my support, then check out my online sober community or my 1:1 work. Website: www.soberpowered.com