Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach

Keywords Chronic cough, TRP receptors, P2X3 receptors, neuroplasticity, allergy, immunology, ATP release, bronchial epithelial cells, therapeutic approaches, research     Summary: In this episode of the Clinical and Experimental Allergy podcast, Dr. Jonathan Bernstein discusses his research on chronic cough, focusing on the role of TRP receptors and P2X3 receptors in understanding the mechanisms behind this condition. He shares insights from his in vitro studies, unexpected findings related to chronic cough pathways, and potential future therapeutic approaches targeting these receptors.   Takeaways Dr. Bernstein is a professor of medicine at the University of Cincinnati. His research focuses on chronic cough and its underlying mechanisms. In vitro assays help isolate different cell activation pathways. ATP release is critical for activating P2X3 receptors on bronchial epithelial cells. Unexpected pathways activated by ATP include FAC signaling and IL-4. P2X3 antagonists can down-regulate pathways promoting airway inflammation. TRP receptors are the first interface between the body and the environment. Nonspecific triggers can activate TRP receptors, leading to increased ATP release. Selective antagonists for TRP receptors are still lacking. The nervous system plays a critical role in cough reflex mechanisms.

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Summary This conversation highlights the significant contributions of the Clinical and Experimental Allergy (CEA) journal to the field of allergy research and clinical practice. The hosts and Editors-In-Chief discuss the journal’s achievements, including advancements in allergy diagnosis, innovative treatments, and a focus on patient-centric research. They also outline future directions for the journal, emphasising collaboration and accessibility in allergy research. Takeaways - CEA is a leading publication in allergy and immunology. - The journal publishes groundbreaking research on allergy mechanisms. - Innovative diagnostic methods are a focus of CEA’s contributions. - Promising new treatments, including biologics, are showcased. - Food allergy research informs better management practices. - Environmental factors influencing allergies are examined. - Patient-reported outcomes are prioritised in research. - The journal’s Impact Factor has reached a record high. - Future plans include enhancing author support and engagement. - Collaboration with patient organisations is a key focus for CEA.