Christina Applegate and Jamie-Lynn Sigler

Jamie-Lynn Sigler feels giddy about being Conan O’Brien’s friend. Christina Applegate feels awesome about being Conan O’Brien’s friend. Jamie-Lynn and Christina sit down with Conan to discuss their respective MS diagnoses, exploring growth and self-reflection on their podcast MeSsy, and why it’s so important to get specific about your vulnerability. Later, Matt Gourley reveals his family’s eerily accurate Oscars fashion predictions. For Conan videos, tour dates and more visit TeamCoco.com. Got a question for Conan? Call our voicemail: (669) 587-2847.

Om Podcasten

After 25 years at the Late Night desk, Conan realized that the only people at his holiday party are the men and women who work for him. Over the years and despite thousands of interviews, Conan has never made a real and lasting friendship with any of his celebrity guests. So, he started a podcast to do just that. Deeper, unboundedly playful, and free from FCC regulations, Conan O’Brien Needs a Friend is a weekly opportunity for Conan to hang out with the people he enjoys most and perhaps find some real friendship along the way. Subscribe to SiriusXM Podcasts+ to listen to new episodes of Conan O'Brien Needs a Friend ad-free and a whole week early. Start a free trial now on Apple Podcasts or by visiting siriusxm.com/podcastsplus.