JPGN Journal Club: December 2024

December’s almost here, can you believe it ?  Here’s JPGN Journal Club, led by Dr Jake Mann !  Don’t forget ESPGHAN’s other educational offerings :  https://www.espghan.org/knowledge-center – on XII.27 the MOOC Enteral Nutrition in Preterm Infants conference, on 2025.I.01 the Young ESPGHAN Mentorship Programme, on I.15 the GI Winter School, and on I.30 the Monothematic Conference on Steatotic Liver Disease in Children.    Jake’s choices for discussion today :  From J Pediatr Gastroenterol Nutr, by Tessler et al., “The association of human milk intake and outcomes in biliary atresia”, and from Cell, by Jena et al., “Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair”.  We learn from the JPGN article that whilst high-energy formula feeding may be recommended in patients with extrahepatic biliary atresia, a diet that includes some human milk helps infants grow better than does one of formula alone, albeit without significant impact on a variety of other parameters.  From the Cell article we learn that in both radiation enteritis and inflammatory bowel disease, gut damage and repair alter DNA configuration to yield Z-nucleic acids, which in combination with Z-DNA binding protein (Z-DBP) activate caspase-8.  This then cleaves gasdermin C, which triggers inflammatory cell death, or pyroptosis (distinct from apoptosis, non-inflammatory cell death).  Type III interferon induces the up-regulation of Z-DBP, promoting pyroptosis.  Agents that modulate type III interferon expression or activity thus may lessen injury in inflammatory bowel disease.     Literature Tessler MEM et al.  The association of human milk intake and outcomes in biliary atresia.  J Pediatr Gastroenterol Nutr 2024 Nov 11.  DOI :  10.1002/jpn3.12403.  PMID :  39526563   Jena KK et al.  Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair.  Cell 2024 Oct 30 S0092-8674(24)01158-9.  DOI :  10.1016/j.cell.2024.10.010.  PMID :  39500322   

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Stay updated with the latest developments in Paediatric Gastroenterology, Hepatology, and Nutrition (PGHN) and get to know the experts behind the research and our organisation. The official podcast of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) explores cutting-edge studies, practice management strategies, and more. Join us three times a month for insightful interviews and commentary with leading professionals in the field, designed to enhance your knowledge and advance your expertise. Our podcast features specialists from around the world, with a particular emphasis on the European community. This podcast is hosted by the ESPGHAN Education Committee. Disclaimer: Opinions expressed in this podcast are those of the guest invited and do not necessarily reflect the views or positions of ESPGHAN. These opinions are based on information and scientific data available at the time of recording and may change as research in the field advances. New Episodes 1st, 10th  and 20th of the Month. For feedback, contact us: office@espghan.org | Playlist: ESPGHAN favourite Songs can be found on Spotify https://open.spotify.com/playlist/0YIHKjxITLEm9XNyHyypTo