77. How Seed Oils Destroy Your Mitochondria and Lead To Chronic Disease, with Tucker Goodrich
Tucker Goodrich is a technology executive in the financial industry who designs, runs, and debugs complex systems in high-risk environments. Areas of expertise include risk management, systems management, and cyber-security. After experiencing some personal health crises and realizing that the ‘solutions’ offered by medical professionals weren’t working or addressing causation he started applying the same approach in research and evaluation of data to his own health issues to determine root causes. His interests have focused on dietary and environmental drivers of chronic disease, including carbohydrate, wheat, and various classes of fats. Specifically, he's attempting to understand and popularize understanding of the mechanisms driving the diet-derived explosion in so-called chronic diseases (or diseases of civilization). He is active on twitter (@tuckergoodrich, has a blog called Yelling Stop, is an Expert Advisor for the nutrition start-up Nutrita, and has been a guest on numerous podcasts. Time Stamps: Podcast Youtube 0:09:38 0:03:21 Podcast Begins 0:11:12 0:04:55 What is Linoleic Acid? 0:16:44 0:10:27 How Linoleic acid caused disease 0:21:06 0:14:49 Understanding cardiolipin and the electron transport chain 0:23:28 0:17:11 Linoleic acid drives mitochondrial dysfunction, causes chronic illness 0:26:41 0:20:24 Maintenance of Cardiolipin and Crista Structure Requires Cooperative Functions of Mitochondrial Dynamics and Phospholipid Transport https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026740/ 0:32:56 0:26:39 Linoleic acid is uniquely damaging 0:35:30 0:29:13 Myths surrounding linoleic acid 0:38:19 0:32:02 The supremacy of animal fats 0:41:05 0:34:48 Brief episode of STZ-induced hyperglycemia produces cardiac abnormalities in rats fed a diet rich in n-6 PUFA https://journals.physiology.org/doi/full/10.1152/ajpheart.00480.2004?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org 0:42:25 0:36:08 How seed oil consumption leads to necrosis and CVD 0:49:38 0:43:21 Mainstream understanding of PUFAs is built on faulty epidemiology 0:56:21 0:50:04 Circulating levels of linoleic acid and HDL-cholesterol are major determinants of 4-hydroxynonenal protein adducts in patients with heart failurehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909262/