Bacteriophages

Melvyn Bragg and guests discuss the most abundant lifeform on Earth: the viruses that 'eat' bacteria. Early in the 20th century, scientists noticed that something in their Petri dishes was making bacteria disappear and they called these bacteriophages, things that eat bacteria. From studying these phages, it soon became clear that they offered countless real or potential benefits for understanding our world, from the tracking of diseases to helping unlock the secrets of DNA to treatments for long term bacterial infections. With further research, they could be an answer to the growing problem of antibiotic resistance.With Martha Clokie Director for the Centre for Phage Research and Professor of Microbiology at the University of LeicesterJames Ebdon Professor of Environmental Microbiology at the University of BrightonAnd Claas Kirchhelle Historian and Chargé de Recherche at the French National Institute of Health and Medical Research’s CERMES3 Unit in Paris.Producer: Simon TillotsonIn Our Time is a BBC Studios Audio ProductionReading list: James Ebdon, ‘Tackling sources of contamination in water: The age of phage’ (Microbiologist, Society for Applied Microbiology, Vol 20.1, 2022) Thomas Häusler, Viruses vs. Superbugs: A Solution to the Antibiotics Crisis? (Palgrave Macmillan, 2006)Tom Ireland, The Good Virus: The Untold Story of Phages: The Mysterious Microbes that Rule Our World, Shape Our Health and Can Save Our Future (Hodder Press, 2024)Claas Kirchhelle and Charlotte Kirchhelle, ‘Northern Normal–Laboratory Networks, Microbial Culture Collections, and Taxonomies of Power (1939-2000)’ (SocArXiv Papers, 2024) Dmitriy Myelnikov, ‘An alternative cure: the adoption and survival of bacteriophage therapy in the USSR, 1922–1955’ (Journal of the History of Medicine and Allied Sciences 73, no. 4, 2018)Forest Rohwer, Merry Youle, Heather Maughan and Nao Hisakawa, Life in our Phage World: A Centennial Field Guide to Earth’s most Diverse Inhabitants (Wholon, 2014)Steffanie Strathdee and Thomas Patterson (2019) The Perfect Predator: A Scientist’s Race to Save Her Husband from a Deadly Superbug: A Memoir (Hachette Books, 2020)William C. Summers, Félix d`Herelle and the Origins of Molecular Biology (Yale University Press, 1999)William C. Summers, The American Phage Group: Founders of Molecular Biology (University Press, 2023)

Om Podcasten

Spanning history, religion, culture, science and philosophy, In Our Time from BBC Radio 4 is essential listening for the intellectually curious. In each episode, host Melvyn Bragg and expert guests explore the characters, events and discoveries that have shaped our world. History fans can learn about pivotal wars and societal upheavals, such as the rise and fall of Napoleon, the Sack of Rome in 1527, and the political intrigue of the Russian Revolution. Those fascinated by the lives of kings and queens can journey to Versailles to meet Marie Antoinette and Louis XIV the Sun King, or to Ancient Egypt to meet Cleopatra and Nerfertiti. Or perhaps you’re looking to explore the history of religion, from Buddhism’s early teachings to the Protestant Reformation. If you’re interested in the stories behind iconic works of art, music and literature, dive in to discussions on the artistic genius of Michelangelo's Sistine Chapel and Van Gogh’s famous Sunflowers. From Gothic architecture to the works of Shakespeare, each episode of In Our Time offers new insight into humanity’s cultural achievements. Those looking to enrich their scientific knowledge can hear episodes on black holes, the Periodic Table, and classical theories of gravity, motion, evolution and relativity. Learn how the discovery of penicillin revolutionised medicine, and how the death of stars can lead to the formation of new planets. Lovers of philosophy will find episodes on the big issues that define existence, from free will and ethics, to liberty and justice. In what ways did celebrated philosophers such as Mary Wollstonecraft and Karl Marx push forward radical new ideas? How has the concept of karma evolved from the ancient Sanskrit texts of Hinduism to today? What was Plato’s concept of an ideal republic, and how did he explore this through the legend of the lost city of Atlantis? In Our Time celebrates the pursuit of knowledge and the enduring power of ideas.