165: E. coli: NDM and PBP variants

As a new microbiologist sometimes terms like beta-lactams, beta-lactamases, or penicillin-binding proteins (PBPs) can be confusing. Are you familiar with the New-Delhi metallo-beta-lactamase (NDM) and its variants? How many are there? How does this enzyme affect beta-lactam drugs?How about NDM-5? In this episode Luis is joined by Dr. Raneem Pallotta, an infectious diseases pharmacist. In the episode we go over these terms. Dr. Pallotta also talks about an NDM-producing E. coli that harbors PBP3 variants. How do these variants affect beta-lactam antibiotics? Tune in for a great episode.Link to Dr. Pallotta's article: https://www.contagionlive.com/view/ndm-producing-e-coli-harboring-pbp-insert-variants-emerges-as-new-threatLink to other articles: https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-017-1012-8https://pmc.ncbi.nlm.nih.gov/articles/PMC5527577/https://pubmed.ncbi.nlm.nih.gov/34800710/https://pubmed.ncbi.nlm.nih.gov/32040179/https://pubmed.ncbi.nlm.nih.gov/25634992/https://www.idsociety.org/practice-guideline/amr-guidance/Questions? Feedback? Send those to letstalkmicro@outlook.comWant to support the podcast? Here's how:Venmo: https://venmo.com/u/letstalkmicroBuy me a Ko-fi: https://ko-fi.com/letstalkmicro

Om Podcasten

A Microbiology podcast where clinical microbiology is explained in simple terms, suitable for students and microbiologists alike. Let's Talk Micro has content about organisms, reactions, infectious diseases, and more. Hosted by Luis Plaza, a Medical Laboratory Scientist and microbiologist, who also shares his experiences in the field.