How Fast Are You Aging? Understanding the Dunedin Pace and the Power of Epigenetics - Episode 262
In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden interviews Hannah Went, co-founder of TrueAge, a leading omics age company. They discuss the significance of epigenetics in understanding biological age, the predictive power of various aging clocks, and the advancements in measuring biological age through multi-omics approaches. The conversation also covers the impact of interventions like caloric restriction on aging metrics, the Dunedin Pace as a new metric for biological aging, and the complexity of aging as a multifactorial process. Went shares insights into the future of epigenetic research and the importance of actionable insights for health optimization. For the audience: * Use the code 'Podcast10' to get 10% OFF your order at our supplement store → https://gladdenlongevityshop.com/ Takeaways * Epigenetic markers can predict chronological age with high accuracy. * GrimAge is a new clock that estimates mortality risk. * Multi-omics approaches provide a comprehensive view of aging. * Caloric restriction significantly impacts biological age. * Dunedin Pace measures the rate of biological aging. * Aging is a complex, multifactorial process. * Understanding what tests do not measure is crucial. * New biomarkers for aging are being developed and validated. Chapters 00:00 Introduction to Omics Age and TrueAge 04:12 The Evolution of Epigenetic Clocks 07:55 Integrating Lifestyle Factors in Omics Age Testing 10:14 Predicting Disease Risk and Mortality with Omics Age 13:27 Reversing Biological Age with Interventions 16:42 Actionable Insights from Omics Age Testing 26:30 Exploring the Impact of Caloric Restriction on Aging 29:08 Understanding the Dunedin Pace as a Measure of Biological Aging 33:32 The Complexity of Aging and the Limitations of Single Metrics 35:24 Epigenetic Biomarker Proxies: A Comprehensive Approach to Aging 43:59 Cell Reprogramming and its Implications for Aging 49:24 Goodbye Learn more about TruAge and/or contact them: Email: hannah@trudiagnostic.com Website: https://www.trudiagnostic.com/ Facebook: https://www.facebook.com/TruDiagnostic/ Instagram: https://www.instagram.com/trudiagnosticofficial/ X: https://x.com/TruDiagnostic YouTube: https://www.youtube.com/c/trudiagnostic TikTok: https://www.tiktok.com/@trudiagnostic?is_from_webapp=1&sender_device=pc LinkedIn: https://www.linkedin.com/company/trudiagnostic/ Reach out to us! Website: https://gladdenlongevity.com/ Email: podcast@gladdenlongevity.com Facebook: https://www.facebook.com/Gladdenlongevity/ Instagram: https://www.instagram.com/gladdenlongevity/?hl=en LinkedIn: https://www.linkedin.com/company/gladdenlongevity YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw