Getting to the Bottom of My Health: Biotin and (V)LCAD

For nearly 20 years, I have strongly suspected that I have a genetic disorder in synthesizing or recycling something that is absent or poorly available from plant foods, is very rich in organ meats, and is not present in any of the supplements I was taking when I was a vegan. After six months of research, testing, and self-experimenting, I now believe what I have been looking for is a mix of moderate genetic defects in biotin recycling, possibly combined with poor cellular uptake of biotin, and definitely combined with a defect in burning long-chain fatty acids for energy. The treatments for this, which I will be testing one at a time, will be high-dose biotin, high-dose riboflavin, possibly high-dose L-carnitine and glycine, and, if needed, an otherwise low-fat diet supplemented with C8-specific MCT oil. This episode covers the content of the first of two articles I have written up on Substack. First, I have a free gift for you: my MTHFR Protocol. This 7-page quick guide to optimizing your MTHFR status using foods and supplements is freely available to all subscribers to my Substack. Subscribe now and you will immediately get it emailed to you in the welcome email. You can subscribe here: https://chrismasterjohnphd.substack.com/p/mthfr-protocol The content of this episode can be found in the written version, with live links, here: https://chrismasterjohnphd.substack.com/p/getting-to-the-bottom-of-my-health  The second article that will be covered in the next episode is about my self-experiments between September 2022 and June 2023 in the "biochemically unoptimized state" and can be found here:   https://chrismasterjohnphd.substack.com/p/self-experiments-in-the-biochemically 

Om Podcasten

Welcome to the Mastering Nutrition podcast. Mastering Nutrition is hosted by Chris Masterjohn, a nutrition scientist focused on optimizing mitochondrial health, and founder of BioOptHealth, a program that uses whole genome sequencing, a comprehensive suite of biochemical data, cutting-edge research and deep scientific insights to optimize each person's metabolism by finding their own unique unlocks. He received his PhD in Nutritional Sciences from University of Connecticut at Storrs in 2012, served as a postdoctoral research associate in the Comparative Biosciences department of the University of Illinois at Urbana-Champaign's College of Veterinary Medicine from 2012-2014, served as Assistant Professor of Health and Nutrition Sciences at Brooklyn College from 2014-2017, and now works independently in science research and education.