S1 Episode 3: Behind the Scenes: Pig-to-Human Kidney Xenotransplantation at The University of Alabama

Drs Sparks and Kumar go behind the scenes and discuss the preparation, surgery, and outcome of the pig-to-human kidney xenotransplantation at The University of Alabama. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/971886). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals. Resources The Advancing American Kidney Health Initiative https://www.kidney.org/advocacy/advancing-american-kidney-health-initiative Nearly 106,000 U.S. Residents Are Waiting for a Lifesaving Transplant https://www.washingtonpost.com/health/2022/05/24/organ-transplant-waiting-list-numbers/ UNOS Patients on the Waiting List vs. Transplants Performed by Organ (2021) https://www.organdonor.gov/learn/organ-donation-statistics/detailed-description#fig1 First Clinical-Grade Porcine Kidney Xenotransplant Using a Human Decedent Model https://onlinelibrary.wiley.com/doi/abs/10.1111/ajt.16930 Mathieu Jaboulay's (1860–1913) Contribution to Xenotransplantation https://onlinelibrary.wiley.com/doi/10.1111/xen.12765 Alexis Carrel - Biographical https://www.nobelprize.org/prizes/medicine/1912/carrel/biographical/ 5 Things to Know About CRISPR https://www.medscape.com/viewarticle/899354 Organ Donation and Transplantation Alliance https://www.organdonationalliance.org/ When Pigs Fly https://onlinelibrary.wiley.com/doi/10.1111/ajt.16963 C4d Staining in Renal Allograft Biopsies With Early Acute Rejection and Subsequent Clinical Outcome https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087790/ Results of Two Cases of Pig-to-Human Kidney Xenotransplantation https://www.nejm.org/doi/10.1056/NEJMoa2120238 University of Maryland School of Medicine Faculty Scientists and Clinicians Perform Historic First Successful Transplant of Porcine Heart Into Adult Human With End-stage Heart Disease https://www.medschool.umaryland.edu/news/2022/University-of-Maryland-School-of-Medicine-Faculty-Scientists-and-Clinicians-Perform-Historic-First-Successful-Transplant-of-Porcine-Heart-into-Adult-Human-with-End-Stage-Heart-Disease.html Thomas E. Starzl Transplantation Institute http://www.stiresearch.health.pitt.edu/about

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Listen to Medscape InDiscussion: Chronic Kidney Disease, a podcast series where thought leaders and clinical experts share their diverse insights and practical ideas for optimizing patient care. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/991189). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.