S1 Episode 5: The Role of Sleep in Major Depressive Disorder
Drs Madhukar Trivedi and Andrew Krystal disentangle the complex relationship between sleep and major depressive disorder. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/968560). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Biomarkers of Depression and Treatment Response (SUNSET) https://clinicaltrials.gov/ct2/show/NCT04581902 Customized Brain Stimulation: New Hope for Severe Depression https://www.medscape.com/viewarticle/960276 Closed-Loop Deep Brain Stimulation for Major Depression (PReSiDio) https://clinicaltrials.gov/ct2/show/NCT04004169 Insomnia in Patients With Depression: A STAR*D Report https://www.cambridge.org/core/journals/cns-spectrums/article/abs/insomnia-in-patients-with-depression-a-stard-report/2C9EB9396B44FD201E15927874FADC05 Prevalence of Obstructive Sleep Apnea in Suicidal Patients With Major Depressive Disorder https://www.sciencedirect.com/science/article/abs/pii/S0022395619302018?via%3Dihub Sleep Disorders as Core Symptoms of Depression https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181883/ Treating Insomnia in Depression: Insomnia Related Factors Predict Long-term Depression Trajectories https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841584/ Mirtazapine Tablet - Uses, Side Effects, and More https://www.webmd.com/drugs/2/drug-13706-4047/mirtazapine-oral/mirtazapine-oral/details Cognitive Behavioral Insomnia Therapy for Those With Insomnia and Depression: A Randomized Controlled Clinical Trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806549/ Efficacy of Cognitive-Behavioral Therapy for Insomnia Combined With Antidepressant Pharmacotherapy in Patients With Comorbid Depression and Insomnia: A Randomized Controlled Trial https://www.psychiatrist.com/jcp/depression/cbt-for-insomnia-in-patients-with-comorbid-depression-and-insomnia/ Cognitive Behavioural Therapy for Insomnia (CBT-I) to Treat Depression: A Systematic Review https://www.sciencedirect.com/science/article/abs/pii/S0022399917308486 Eszopiclone - Uses, Side Effects, and More https://www.webmd.com/drugs/2/drug-92330/eszopiclone-oral/details Eszopiclone Co-Administered With Fluoxetine in Patients With Insomnia Coexisting With Major Depressive Disorder https://www.biologicalpsychiatryjournal.com/article/S0006-3223(06)00185-5/fulltext brexanolone (Rx) https://reference.medscape.com/drug/zulresso-brexanolone-1000299 Sleep Disturbances as an Evidence-Based Suicide Risk Factor https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613558/ Reducing Suicidal Ideation Through Insomnia Treatment (REST-IT): A Randomized Clinical Trial https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2019.19030267 Insomnia Severity Index (ISI) https://reference.medscape.com/calculator/820/insomnia-severity-index-isi