Pixels to Protocols: Building the AI Future of Pathology with Dr. Faisal Mahmood

Dr. Faisal Mahmood, Associate Professor of Pathology at Brigham and Women’s Hospital and Harvard Medical School, joins hosts Raj Manrai and Andy Beam on NEJM AI Grand Rounds to explore the frontier of computational pathology. From pioneering foundational models for whole slide imaging to commercializing a multimodal generative AI copilot for pathology, Faisal shares how his team is redefining what’s possible in digital diagnostics. He discusses the power of open-source culture in accelerating innovation, his lab’s FDA breakthrough designation, and how generative AI could trigger widespread digitization in pathology. Faisal also reflects on his creative approach to problem selection and offers a vision for a future shaped by patient-level foundation models and agent-led computational biology. Transcript.

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NEJM AI Grand Rounds, hosted by Arjun (Raj) Manrai, Ph.D. and Andrew Beam, Ph.D., features informal conversations with a variety of unique experts exploring the deep issues at the intersection of artificial intelligence, machine learning, and medicine. You’ll learn how AI will change clinical practice and healthcare, how it will impact the patient experience, and about the people who are pushing for innovation. Whether you are an AI researcher or a practicing clinician, these conversations will enlighten and surprise you as we journey through this very exciting field. Produced by NEJM Group.