Multiple Myeloma | Oncology Today with Dr Neil Love: BCMA-Directed Therapies for Multiple Myeloma
Featuring an interview with Dr Amrita Krishnan, including the following topics: Case: A woman in her early 60s who presents with renal failure and receives CyBorD for multiple myeloma (MM) (0:00) Dyspnea associated with carfilzomib; ocular toxicity with belantamab mafodotin (6:26) Efficacy, tolerability and sequencing of belantamab mafodotin for MM; myths and misperceptions (10:33) Case: A man in his early 70s who presents with back pain and compression fractures; efficacy of bispecific antibodies compared to chimeric antigen receptor (CAR) T-cell therapy (17:40) Emerging data with the GPRC5D-targeted bispecific antibody talquetamab; similarities and differences in the pharmacology of BCMA-targeted bispecific antibodies for MM (25:31) Case: A man in his mid 50s who presents with severe back pain and an L5 mass (30:22) Diagnosis and management of cytokine release syndrome, neurotoxicity and infectious complications with CAR T-cell therapy (35:05) Future roles of bispecific antibodies, CAR T-cell therapy and transplantation in the treatment of MM; eligibility criteria for patients to receive CAR T-cell therapy (44:06) CME information and select publications