Pulm| Pickwickian Syndrome (Obesity Hypoventilation Syndrome)
2.17 Pickwickian Syndrome Pulmonary system review for the USMLE Step 1 Exam Pickwickian Syndrome is also called obesity hypoventilation syndrome Characterized by daytime hypoventilation leading to hypercapnia Often occurs in individuals with a BMI over 30 Excess fat puts pressure on lungs and reduces ability to fully inflate Reduction in ventilatory drive may also cause hypercapnia Typical patient presents with obesity, daytime sleepiness, and symptoms consistent with obstructive sleep apnea Diagnosis confirmed by arterial blood gas Short term treatment with positive airway pressure therapy Long term treatment involves lifestyle changes to lose weight CPAP machine supplies positive pressure to reduce CO2 build up Weight loss relieves symptoms by reducing excess weight on lungs.