PREVIEW Aliquot #18: The dual nature of IGF-1: Striking a balance for optimal health

Insulin-like growth factor-1, or IGF-1 for short, is a protein that plays critical roles in major growth pathways in the human body. It influences nearly every tissue in the body, especially developmental growth, skeletal muscle and neurons. Emerging evidence suggests that IGF-1 also regulates the aging process. Overactivity of IGF-1 has been implicated in aging and age-related diseases, such as cancer. Balancing the beneficial and (sometimes) harmful effects of IGF-1 via exercise and fasting is critical to maintaining health.  In this episode, we discuss: (00:00) Introduction (03:23) The role of both mTOR and the IGF-1 pathway in cellular growth and their regulation by amino acids (Peter Attia discussion) (11:50) Living longer as a function of preventing insidious damage to our cells and tissues (14:53) Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans (Valter Longo discussion) (17:10) Effects of IGF-1 on human lifespan (23:01) Refeeding that follows fasting mimicking creates an environment that may be just right for the regeneration of healthy cells (25:55) The growth-longevity trade-off (Rhonda Patrick & Mike Maser discussion) You can see the original full interview with Dr. Attia    You can see the original full interview with Dr. Longo   You can hear the original full interview with Dr. Rhonda Patrick and Mike Maser   Get more Aliquots! Become a FMF Premium member and get full access to our members-only podcast, The Aliquot, plus live Q&As with Rhonda, biweekly Science Digest emails, and more.   Learn more and sign up at: www.foundmyfitness.com/crowdsponsor

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This is the Aliquot Preview - a sneak peek into FoundMyFitness’s members-only podcast: The Aliquot. Learn more about The Aliquot at foundmyfitness.com/aliquot. Every month we release one free preview episode here so you can sample one of the many FoundMyFitness Premium Membership benefits. So what is an aliquot? An aliquot is a sample taken from a larger whole, that captures the essence of the entirety. FoundMyFitness Aliquots are short, members-only podcasts focused on single topics, curated and remixed to surface our richest content on the most popular topics like diet and nutrition, health span and life extension, exercise, fasting, ketosis, sauna and cold exposure, sleep and depression. Some episodes are edited excerpts, highlights, and informative moments taken from full interviews in the FoundMyFitness podcast (with a little more context from Dr Rhonda Patrick!) Other episodes are mash-ups and highlights from our regular Q&As with members. Become a FoundMyFitness Premium member to get access to weekly Aliquots, biweekly Science Digest emails, and monthly Q&As with Rhonda. Learn more at foundmyfitness.com/crowdsponsor.