The Aliquot Preview

PREVIEW Aliquot #6: Genetic and lifestyle risk factors for Alzheimer's disease

av The Aliquot Preview | Publicerades 2/25/2021

The single most important genetic risk factor for Alzheimer's disease is a variant of apolipoprotein E, or APOE for short, a lipoprotein produced in the liver and brain. Roughly a quarter of all people living in the US – about 75 million people – carry a genetic variant of APOE called APOE4. Having APOE4 is associated with higher circulating levels of LDL cholesterol and an increased risk for Alzheimer's disease.    But having APOE4 doesn't mean that Alzheimer's disease is inevitable. In fact, lifestyle behaviors can modulate risk for the disease, too, especially sleep, which provides an opportunity to rid the brain of toxic metabolic byproducts that can contribute to Alzheimer's disease risk. Understanding our genetic risks and addressing lifestyle behaviors – especially our sleep patterns – can influence whether a person eventually develops Alzheimer's disease.   These Aliquot segments feature Dr. Charles Raison, a professor of psychiatry, and Dr. Matthew Walker, a professor of neuroscience and psychology.   You can see the original full interview with Dr. Raison on YouTube:   FoundMyFitness episode page:   You can see the original full interview with Dr. Walker on YouTube:   FoundMyFitness episode page:

Om Podcasten

This is the Aliquot Preview — a sneak peek into FoundMyFitness’ members-only podcast: The Aliquot. The Aliquot Preview Podcast gives you access to one sample Aliquot episode every month. For mash-up episodes, you'll get to listen to 15-20 minutes for free, and for regular Aliquots, you get to listen to the whole thing! An aliquot is a sample taken from a larger whole, that captures the essence of the entirety. The Aliquots are short, members-only podcasts focused on single topics, curated and remixed from the best of FoundMyFitness. Some episodes of The Aliquot are edited excerpts, highlights, and informative moments taken from full interviews in the FoundMyFitness podcast (with a little more context from Rhonda!). Other episodes are mash-ups of highlights from my regular Q&As. If you love this show (you will!) and want more (than one preview per month), consider becoming a FoundMyFitness Premium member to get weekly Aliquots, biweekly Science Digest emails, and monthly Q&As with Rhonda. Learn more at