Stuart Buck: Making science funding work better

Stuart Buck is the Executive Director of the Good Science Project, a new initiative to make science funding more effective, innovative, and robust. This mission has been the major theme of Stuart’s career; he was previously Vice President of Research at Arnold Ventures, a large philanthropic foundation. In this conversation, we discuss the twin problems of reproducibility and innovation in science, and whether they’re in tension. We talk about whether and why most published research findings are false; how to fix career incentives in science; and why science should embrace red teaming, among many other things.I recommend this essay by Stuart, which I reference during the conversation. The book I reference, The Enigma of Reason, is here and the review Stuart mentions is here.-----------------Thanks to Cofruition for consulting on and producing the show. You can learn more about Entrepreneur First at and subscribe to my weekly newsletter at

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Matt Clifford, co-founder of Entrepreneur First, interviews the people behind some of the world's most important ideas. We explore in-depth some of the fastest-changing and most impactful areas of life, from technology to geopolitics and scientific progress to entrepreneurship. Guests include founders, investors, academics and journalists working and thinking at the frontier of these topics.Subscribe to the free weekly newsletter at