Placebos work. Why?

For decades, scientists thought that placebos only worked if patients didn’t know they were taking them. Not anymore: You can give patients placebos, tell them they’re on sugar pills, and they still might feel better. No one is sure how this works, but it raises a question: Should doctors embrace placebos in mainstream medicine? (First published in 2021.) Guests: Ted Kaptchuk, professor at Harvard Medical School; Darwin Guevarra, professor of psychology at Miami University; Luana Colloca, professor at the University of Maryland School of Nursing For show transcripts, go to vox.com/unxtranscripts For more, go to vox.com/unexplainable And please email us! unexplainable@vox.com We read every email. Support Unexplainable by becoming a Vox Member today: vox.com/members Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Unexplainable takes listeners right up to the edge of what we know … and then keeps on going. Host Noam Hassenfeld and an all-star team of reporters — Byrd Pinkerton, Meradith Hoddinott, and Mandy Nguyen — tackle scientific mysteries, unanswered questions, and everything we learn by diving into the unknown. New episodes drop every Wednesday.