Should you be eating poison oak?

Probably not. But Wall Street Journal reporter Jeff Horwitz decided to try anyway, putting his body — and specifically his butt — on the line to answer a seemingly straightforward question: Is it possible to build up a tolerance to poison oak by eating it? Guest: Jeff Horwitz, reporter at the Wall Street Journal; and Mahmoud ElSohly, professor of pharmaceutics at the University of Mississippi For show transcripts, go to vox.com/unxtranscripts For more, go to vox.com/unexplainable And please email us! unexplainable@vox.com We read every email. Support Unexplainable by becoming a Vox Member today: vox.com/members Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Unexplainable takes listeners right up to the edge of what we know … and then keeps on going. Host Noam Hassenfeld and an all-star team of reporters — Byrd Pinkerton, Meradith Hoddinott, and Mandy Nguyen — tackle scientific mysteries, unanswered questions, and everything we learn by diving into the unknown. New episodes drop every Wednesday.